Baur P S, Barratt G F, Brown G M, Parks D H
J Trauma. 1979 Oct;19(10):744-56. doi: 10.1097/00005373-197910000-00006.
We have observed, by light and electron microscopy, fibroblast-like cells which appear to be involved in collagen fiber and filament degradation. These cells are most prominent in the dermis of mature hypertrophic scars which were clinically observed to be in the remodeling phase of wound repair. Total incorporation of collagen filaments within cellular vacuoles, as seen by TEM, appears to precede the enzymatic degradation of the collagen. Cytoplasmic contractile bundles and/or collagen filament remnants found within residual lysosomes were also seen in many of these cells. Evidence of structural reorganization within the tissue was observed by means of SEM. These cells appear to be similar to osteoclasts in function: thus we propose to name them "fibroclasts" and "myofibroclasts."
通过光学显微镜和电子显微镜观察，我们发现了成纤维细胞样细胞，它们似乎参与了胶原纤维和细丝的降解。这些细胞在成熟肥厚性瘢痕的真皮中最为显著，临床上观察到这些瘢痕正处于伤口修复的重塑阶段。透射电镜观察显示，胶原细丝在细胞液泡中的完全摄取似乎先于胶原的酶促降解。在许多这类细胞中还可见到残留溶酶体内的细胞质收缩束和/或胶原细丝残余物。通过扫描电子显微镜观察到了组织内结构重组的证据。这些细胞在功能上似乎与破骨细胞相似：因此我们提议将它们命名为“纤维破骨细胞”和“肌纤维破骨细胞”。
