Lefebvre Y
Can Med Assoc J. 1970 Mar 28;102(6):621-4.
The hormonal contraceptives seem to have no direct effect on cervical carcinoma or dysplasia, but they are responsible for the appearance of glandular adenomatous hyperplasia of the endocervix.The long-term use of progestins is responsible for the inactive appearance of the ovaries, with thickening of the tunica albuginea, rare follicle growth, occasional fibrosis of the stroma and a decreased DNA formation.After stopping oral and injectable hormonal contraceptives the first cycle is usually long and cases of amenorrhea have been reported. The causes of secondary amenorrhea probably lie in the hypothalamus and/or the ovaries.The time lapse between cessation of oral contraception and conception is between 5.8 and 6.5 months. No increase in abortion has been noted, but abortuses and ova have an increased polyploid tendency and incidence of chromosome breaks. Further investigations of larger series are necessary to provide definite proof. Meanwhile it would seem advisable that after cessation of hormonal contraception there should be a time lapse of six to eight months before a patient becomes pregnant.
激素避孕药似乎对宫颈癌或发育异常没有直接影响，但它们会导致宫颈内膜出现腺腺瘤样增生。长期使用孕激素会导致卵巢外观无活性，白膜增厚，卵泡生长稀少，间质偶尔纤维化，DNA形成减少。停用口服和注射用激素避孕药后，第一个周期通常较长，且有闭经病例的报道。继发性闭经的原因可能在于下丘脑和/或卵巢。停止口服避孕药与受孕之间的时间间隔在5.8至6.5个月之间。未发现流产率增加，但流产胎儿和卵子的多倍体倾向及染色体断裂发生率增加。需要对更多病例进行进一步研究以提供确切证据。同时，似乎建议在停用激素避孕药后，患者应间隔六至八个月再怀孕。
