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Mechanics of frameshift mutagenesis in bacteriophage T4: role of chromosome tips.噬菌体T4中移码诱变的机制：染色体末端的作用。
Proc Natl Acad Sci U S A. 1970 Mar;65(3):617-24. doi: 10.1073/pnas.65.3.617.
2
Ligase-defective bacteriophage T4. I. Effects on mutation rates.连接酶缺陷型噬菌体T4。I. 对突变率的影响。
J Virol. 1973 Jan;11(1):35-40. doi: 10.1128/JVI.11.1.35-40.1973.
3
Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.噬菌体T4早期功能基因损伤刺激的移码突变回复
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4
Polar mutations in the left arm of bacteriophage lambda i434.噬菌体λi434左臂中的极性突变
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Proflavin treatment of Escherichia coli: generation of frameshift mutations.吖啶黄素对大肠杆菌的处理：移码突变的产生
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Magnesium reversal of proflavine inhibition of bacteriophage T2H.镁对原黄素抑制噬菌体T2H的逆转作用。
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7
Frameshift mutations.移码突变
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Association of induced frameshift mutagenesis and DNA replication in Escherichia coli.大肠杆菌中诱导移码突变与DNA复制的关联
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Acta Microbiol Pol. 1968;17(2):129-34.
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9-Aminoacridine mutagenesis of bacteriophage T4 intracellular DNA.噬菌体T4细胞内DNA的9-氨基吖啶诱变
Mol Gen Genet. 1975 Jul 10;138(4):333-43. doi: 10.1007/BF00264803.

引用本文的文献

1
A species barrier between bacteriophages T2 and T4: exclusion, join-copy and join-cut-copy recombination and mutagenesis in the dCTPase genes.噬菌体T2和T4之间的物种屏障：dCTPase基因中的排除、连接复制和连接切割复制重组及诱变
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2
The influence of neighboring base pairs upon base-pair substitution mutation rates.相邻碱基对对碱基对替换突变率的影响。
Proc Natl Acad Sci U S A. 1971 Apr;68(4):773-6. doi: 10.1073/pnas.68.4.773.
3
Reversion of frameshift mutations stimulated by lesions in early function genes of bacteriophage T4.噬菌体T4早期功能基因损伤刺激的移码突变回复
J Virol. 1971 Apr;7(4):460-6. doi: 10.1128/JVI.7.4.460-466.1971.
4
Ligase-defective bacteriophage T4. I. Effects on mutation rates.连接酶缺陷型噬菌体T4。I. 对突变率的影响。
J Virol. 1973 Jan;11(1):35-40. doi: 10.1128/JVI.11.1.35-40.1973.
5
Inactivation of bacteriophage T4 by ethyl methanesulfonate: influence of host and viral genotypes.甲磺酸乙酯对噬菌体T4的灭活作用：宿主和病毒基因型的影响
J Virol. 1972 Mar;9(3):440-7. doi: 10.1128/JVI.9.3.440-447.1972.
6
Frameshift mutations produced by proflavin in bacteriophage T4: specificity within a hotspot.原黄素在噬菌体T4中产生的移码突变：热点区域内的特异性
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6954-8. doi: 10.1073/pnas.83.18.6954.
7
9-Aminoacridine mutagenesis of bacteriophage T4 intracellular DNA.噬菌体T4细胞内DNA的9-氨基吖啶诱变
Mol Gen Genet. 1975 Jul 10;138(4):333-43. doi: 10.1007/BF00264803.
8
Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex.诱变剂-核酸插入结合：9-氨基吖啶：5-碘胞苷酰（3'-5'）鸟苷晶体复合物的结构
Proc Natl Acad Sci U S A. 1977 Jan;74(1):188-92. doi: 10.1073/pnas.74.1.188.

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Localized Negative Interference in Bacteriophage.噬菌体中的局部负干扰
Genetics. 1965 Mar;51(3):369-79. doi: 10.1093/genetics/51.3.369.
2
MUTATIONAL HETEROZYGOTES IN BACTERIOPHAGES.噬菌体中的突变杂合子
Proc Natl Acad Sci U S A. 1959 Oct;45(10):1507-15. doi: 10.1073/pnas.45.10.1507.
3
Mutagenesis of bacteriophage T4 by acridines.吖啶对噬菌体T4的诱变作用。
J Mol Biol. 1961 Dec;3:762-8. doi: 10.1016/s0022-2836(61)80081-8.
4
MUTAGENIC ACTION DURING MEIOSIS AND ANTIMUTAGENIC ACTION DURING MITOSIS BY 5-AMINOACRIDINE IN YEAST.酵母中5-氨基吖啶在减数分裂期间的诱变作用及在有丝分裂期间的抗诱变作用。
Mutat Res. 1964 Oct;106:227-30. doi: 10.1016/0027-5107(64)90003-x.
5
THE LINKAGE MAP OF BACTERIOPHAGE T4.噬菌体T4的连锁图谱。
Genetics. 1964 Oct;50(4):539-52. doi: 10.1093/genetics/50.4.539.
6
CHROMOSOME STRUCTURE IN PHAGE T4. I. CIRCULARITY OF THE LINKAGE MAP.噬菌体T4中的染色体结构。I. 连锁图谱的环形性
Proc Natl Acad Sci U S A. 1964 May;51(5):775-9. doi: 10.1073/pnas.51.5.775.
7
AN EXPERIMENTAL ANALYSIS OF BACTERIOPHAGE T4 HETEROZYGOTES. I. MOTTLED PLAQUES FROM CROSSES INVOLVING SIX RII LOCI.噬菌体T4杂合子的实验分析。I. 涉及六个RII基因座杂交产生的斑驳噬菌斑
Virology. 1963 Dec;21:551-67. doi: 10.1016/0042-6822(63)90227-7.
8
THE ORIGIN OF SPONTANEOUS MUTATIONS DURING MEIOSIS.减数分裂过程中自发突变的起源
Proc Natl Acad Sci U S A. 1963 Nov;50(5):975-80. doi: 10.1073/pnas.50.5.975.
9
Ethyl methanesulfonate-induced reversion of bacteriophage T4rII mutants.甲磺酸乙酯诱导的噬菌体T4rII突变体回复突变
Genetics. 1963 Apr;48(4):561-80. doi: 10.1093/genetics/48.4.561.
10
The structure of the DNA-acridine complex.DNA-吖啶复合物的结构。
Proc Natl Acad Sci U S A. 1963 Jan 15;49(1):94-102. doi: 10.1073/pnas.49.1.94.

噬菌体T4中移码诱变的机制：染色体末端的作用。

Mechanics of frameshift mutagenesis in bacteriophage T4: role of chromosome tips.

作者信息

Lindstrom D M, Drake J W

出版信息

Proc Natl Acad Sci U S A. 1970 Mar;65(3):617-24. doi: 10.1073/pnas.65.3.617.

DOI:10.1073/pnas.65.3.617
PMID:4910850
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC282951/
Abstract

In contrast to observations in bacteria and fungi, frameshift mutations in bacteriophage T4 do not arise during genetic recombination. Nascent mutants, captured in the heterozygous condition, exhibit properties which indicate that the new lesions are located at the extreme tips of the chromosomes, and are segregated by a combination of recombination and replication.

摘要

与在细菌和真菌中的观察结果相反，噬菌体T4中的移码突变在基因重组过程中不会出现。在杂合状态下捕获的新生突变体表现出的特性表明，新的损伤位于染色体的极端末端，并通过重组和复制的组合进行分离。