诱变剂-核酸插入结合：9-氨基吖啶：5-碘胞苷酰（3'-5'）鸟苷晶体复合物的结构
Mutagen-nucleic acid intercalative binding: structure of a 9-aminoacridine: 5-iodocytidylyl(3'-5')guanosine crystalline complex.
作者信息
Sakore T D, Jain S C, Tsai C C, Sobell H M
出版信息
Proc Natl Acad Sci U S A. 1977 Jan;74(1):188-92. doi: 10.1073/pnas.74.1.188.
Abstract
9-Aminoacridine forms a crystalline complex with the dinucleoside monophosphate, 5-iodocytidylyl(3'-5')guanosine. We have solved the three-dimensional structure of this complex by x-ray crystallography and have observed two distinct intercalative binding modes by this drug to miniature Watson-Crick double helical structures. The first of these involves a pseudosymmetric stacking interaction between 9-aminoacridine molecules and guanine-cytosine base-pairs. This configuration may be used by 9-aminoacridine when intercalating into DNA. The second configuration is an asymmetric interaction, largely governed by stacking forces between acridine and guanine rings. This type of association may play an important role in the mechanism of frameshift mutagenesis.
摘要
9-氨基吖啶与二磷酸核苷5-碘胞苷酰（3'-5'）鸟苷形成晶体复合物。我们通过X射线晶体学解析了该复合物的三维结构，并观察到该药物与微型沃森-克里克双螺旋结构存在两种不同的嵌入结合模式。其中第一种涉及9-氨基吖啶分子与鸟嘌呤-胞嘧啶碱基对之间的假对称堆积相互作用。当9-氨基吖啶嵌入DNA时可能采用这种构型。第二种构型是一种不对称相互作用，主要由吖啶环与鸟嘌呤环之间的堆积力决定。这种结合类型可能在移码诱变机制中起重要作用。
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