Kalden J R, Evans M M, Irvine W J
Immunology. 1970 May;18(5):671-9.
Twenty-one-day-old rats were hypophysectomized or sham-operated and challenged with sheep red blood cells 5 or 21 days after operation. Although the sizes of the bodies and lymphoid organs were greatly decreased in the hypophysectomized animals no significant difference was found in the numbers of plaque forming cells or serum antibody titres against the sheep red blood cells. The hypophysectomized rats showed a cell depletion in the perifollicular zone of the spleen follicles, but no obvious histological changes in the thymus. It is concluded that pituitary hormones are not directly necessary for the formation of humoral antibodies.
将21日龄的大鼠进行垂体切除或假手术，并在术后5天或21天用绵羊红细胞进行攻击。虽然垂体切除动物的身体和淋巴器官大小显著减小，但在针对绵羊红细胞的噬斑形成细胞数量或血清抗体滴度方面未发现显著差异。垂体切除的大鼠脾脏滤泡的滤泡周区出现细胞耗竭，但胸腺无明显组织学变化。结论是垂体激素对于体液抗体的形成并非直接必需。
