• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships.

作者信息

Hansch C, Coats E

出版信息

J Pharm Sci. 1970 Jun;59(6):731-43. doi: 10.1002/jps.2600590602.

DOI:10.1002/jps.2600590602
PMID:4912447
Abstract
摘要

相似文献

1
Alpha-chymotrypsin: a case study of substituent constants and regression analysis in enzymic structure--activity relationships.α-胰凝乳蛋白酶：酶结构-活性关系中取代基常数与回归分析的一个案例研究
J Pharm Sci. 1970 Jun;59(6):731-43. doi: 10.1002/jps.2600590602.
2
Kinetics of the reaction of chymotrypsin A with peptide chloromethyl ketones in relation to its subsite specificity.胰凝乳蛋白酶A与肽氯甲基酮反应的动力学及其亚位点特异性
Biochemistry. 1973 Feb;12(4):771-7. doi: 10.1021/bi00728a029.
3
The topographical differences in the active site region of alpha-chymotrypsin, subtilisin Novo, and subtilisin Carlsberg. Mapping the aromatic binding site by inhibitors (virtual substrates).α-胰凝乳蛋白酶、嗜热栖热菌蛋白酶和枯草杆菌蛋白酶卡尔伯格活性位点区域的拓扑差异。通过抑制剂（虚拟底物）绘制芳香族结合位点。
Biochemistry. 1974 Jan 15;13(2):266-77. doi: 10.1021/bi00699a006.
4
Structure-reactivity correlations and general acid-base catalysis in enzymic transacylation reactions.
Cold Spring Harb Symp Quant Biol. 1972;36:1-11. doi: 10.1101/sqb.1972.036.01.004.
5
Mechanism of chymotrypsin. Structure, reactivity, and nonproductive binding relationships.胰凝乳蛋白酶的作用机制。结构、反应活性及非生产性结合关系。
Biochemistry. 1973 Mar 13;12(6):1067-74. doi: 10.1021/bi00730a008.
6
Binding properties of oligomeric alpha-chymotrypsin.寡聚α-胰凝乳蛋白酶的结合特性
Biochemistry. 1971 Mar 16;10(6):1033-41. doi: 10.1021/bi00782a015.
7
Studies on self-association of proteins. The self-association of alpha-chymotrypsin at pH 8.3 and ionic strength 0.05.蛋白质自缔合的研究。α-胰凝乳蛋白酶在pH 8.3和离子强度0.05条件下的自缔合。
Biochemistry. 1974 Feb 26;13(5):1048-55. doi: 10.1021/bi00702a034.
8
Transient formation of a complex between alpha-chymotrypsin, proflavin, and tosylarginine methyl ester (TAME).
Can J Biochem. 1972 Mar;50(3):257-60. doi: 10.1139/o72-036.
9
Irreversible enzyme inhibitors. 113. Proteolytic enzymes. 3. Active-site-directed irreversible inhibitors of alpha-chymotrypsin derived from phenoxyacetamides with an N-fluorosulfonylphenyl substituent.
J Med Chem. 1968 Mar;11(2):233-41. doi: 10.1021/jm00308a009.
10
Acylation of chymotrypsin by active esters of nonspecific substrates. Evidence for a transient acylimidazole intermediate.非特异性底物活性酯对胰凝乳蛋白酶的酰化作用。关于瞬时酰基咪唑中间体的证据。
Biochemistry. 1972 Jun 20;11(13):2483-93. doi: 10.1021/bi00763a016.

引用本文的文献

1
Stereochemistry and Charged State Influence Effector Outcomes of d-2-Hydroxyglutarate Dehydrogenase Ligands.立体化学和带电状态影响d-2-羟基戊二酸脱氢酶配体的效应物结果。
Biochemistry. 2025 Oct 7;64(19):4170-4180. doi: 10.1021/acs.biochem.5c00408. Epub 2025 Sep 8.
2
New insights into the binding and catalytic mechanisms of Bacillus thuringiensis lactonase: insights into B. thuringiensis AiiA mechanism.苏云金芽孢杆菌内酯酶结合与催化机制的新见解：苏云金芽孢杆菌AiiA机制的见解
PLoS One. 2013 Sep 18;8(9):e75395. doi: 10.1371/journal.pone.0075395. eCollection 2013.
3
Neutralizing positive charges at the surface of a protein lowers its rate of amide hydrogen exchange without altering its structure or increasing its thermostability.
使蛋白质表面的正电荷呈电中性会降低酰胺氢交换的速率，而不会改变其结构或增加其热稳定性。
J Am Chem Soc. 2010 Dec 15;132(49):17411-25. doi: 10.1021/ja9067035. Epub 2010 Nov 19.
4
How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA.端粒蛋白 POT1 如何避免 RNA 以实现对单链 DNA 的特异性。
Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):651-6. doi: 10.1073/pnas.0911099107. Epub 2009 Dec 22.
5
Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation.赖氨酸乙酰化可以产生带高电荷的酶，这些酶对不可逆失活的抗性增强。
Protein Sci. 2008 Aug;17(8):1446-55. doi: 10.1110/ps.035154.108. Epub 2008 May 1.
6
Increasing the net charge and decreasing the hydrophobicity of bovine carbonic anhydrase decreases the rate of denaturation with sodium dodecyl sulfate.增加牛碳酸酐酶的净电荷并降低其疏水性，会降低其与十二烷基硫酸钠的变性速率。
Biophys J. 2006 Jul 1;91(1):298-310. doi: 10.1529/biophysj.106.081547. Epub 2006 Apr 14.
7
Structure-affinity relationships of substrates for the neutral amino acid transport system in rabbit ileum.兔回肠中性氨基酸转运系统底物的结构-亲和力关系
J Gen Physiol. 1974 Oct;64(4):443-67. doi: 10.1085/jgp.64.4.443.
8
Parameter and structure-activity data bases: management for maximum utility.参数与构效数据库：实现最大效用的管理
Environ Health Perspect. 1985 Sep;61:275-85. doi: 10.1289/ehp.8561275.
9
Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases.哺乳动物谷胱甘肽转移酶催化共轭反应中4-羟基烯醛的构效关系。
Biochem J. 1987 Nov 1;247(3):707-13. doi: 10.1042/bj2470707.
10
Prodrugs of peptides. 13. Stabilization of peptide amides against alpha-chymotrypsin by the prodrug approach.
Pharm Res. 1991 Dec;8(12):1533-8. doi: 10.1023/a:1015854718903.