Action of beta-adrenergic blocking agents on the urethral pressure profile.

The action of beta-adrenergic blocking agents on the urethral pressure profile was studied. Sotalol, 20 mg, and inderal, 7 mg, were administered intravenously. Whereas the alpha-adrenergic blocking drug phentolamine, as already known, changed the maximum value of the pressure profile with an average decrease of 33%, the beta-adrenergic blocking drugs did not show any action at all. There was no difference between the results obtained with Sotalol and Inderal.