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健康儿童及患肾病儿童的β2-微球蛋白(作者译)

[beta2-Microglobulin in healthy children and in children with renal diseases (author's transl)].

作者信息

Gekle D, Kult J, Hüttig H, Heidland A

出版信息

Z Kinderheilkd. 1975;119(4):293-8.

PMID:49135
Abstract

beta2 microglobulin is a plasma protein of low molecular weight (11800), which also appears in urine in small quantities and cerebrospinal fluid. Its serum concentration in healthy children is 0.12 plus or minus 0.04 mg/100 ml, its renal excretion is 0.07 plus or minus 0.05 mg/24 hrs. In glomerular nephropathy serum levels are augmented with diminished GFR, while in tubular nephropathy excretion in the urine is raised considerably. There is a close correlation between serum beta2 microglobulin and GFR.

摘要

β2微球蛋白是一种低分子量(11800)的血浆蛋白,也少量出现在尿液和脑脊液中。健康儿童的血清浓度为0.12±0.04mg/100ml,肾脏排泄量为0.07±0.05mg/24小时。在肾小球肾病中,血清水平随肾小球滤过率(GFR)降低而升高,而在肾小管肾病中,尿排泄量显著增加。血清β2微球蛋白与GFR之间存在密切相关性。

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