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Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.

作者信息

Lombardini J B, Coulter A W, Talalay P

出版信息

Mol Pharmacol. 1970 Sep;6(5):481-99.

PMID:4918253
Abstract
摘要

相似文献

1
Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction. Deductions concerning the conformation of methionine.蛋氨酸类似物作为蛋氨酸腺苷转移酶反应的底物和抑制剂。关于蛋氨酸构象的推断。
Mol Pharmacol. 1970 Sep;6(5):481-99.
2
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-l-methionine. I. Saturated and unsaturated aliphatic amino acids.L-甲硫氨酸的结构和构象类似物作为S-腺苷-L-甲硫氨酸酶促合成的抑制剂。I. 饱和和不饱和脂肪族氨基酸。
Mol Pharmacol. 1974 Mar;10(2):293-304.
3
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. II. Aromatic amino acids.L-甲硫氨酸的结构和构象类似物作为S-腺苷-L-甲硫氨酸酶促合成抑制剂。II. 芳香族氨基酸。
Mol Pharmacol. 1974 Mar;10(2):305-14.
4
Structural and conformational analogues of L-methionine as inhibitors of the enzymatic synthesis of S-adenosyl-L-methionine. IV. Further mono-, bi- and tricyclic amino acids.L-甲硫氨酸的结构和构象类似物作为S-腺苷-L-甲硫氨酸酶促合成抑制剂。IV. 进一步的单环、双环和三环氨基酸。
Mol Pharmacol. 1979 May;15(3):661-77.
5
The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding site.大鼠肝脏中四聚体蛋氨酸腺苷转移酶的晶体结构揭示了蛋氨酸结合位点。
J Mol Biol. 2000 Jul 7;300(2):363-75. doi: 10.1006/jmbi.2000.3858.
6
Role of cysteine in the dietary control of the expression of 3-phosphoglycerate dehydrogenase in rat liver.半胱氨酸在大鼠肝脏中3-磷酸甘油酸脱氢酶表达的饮食控制中的作用。
Biochem J. 1999 Nov 15;344 Pt 1(Pt 1):15-21.
7
Reversal by serine and potentiation by glycine of the inhibitory effect of 1,2,4-triazole on growth of Salmonella typhimurium.丝氨酸对1,2,4 - 三唑抑制鼠伤寒沙门氏菌生长的作用具有逆转效果，而甘氨酸则具有增强作用。
Acta Biochim Pol. 1967;14(1):133-41.
8
Sulfur-containing amino acids attenuate the development of liver fibrosis in rats through down-regulation of stellate cell activation.含硫氨基酸通过下调星状细胞活化来减轻大鼠肝纤维化的发展。
J Hepatol. 2004 Jun;40(6):917-25. doi: 10.1016/j.jhep.2004.02.011.
9
The mouse liver content of carbonic anhydrase III and glutathione S-tranferases A3 and P1 depend on dietary supply of methionine and cysteine.小鼠肝脏中碳酸酐酶III、谷胱甘肽S-转移酶A3和P1的含量取决于蛋氨酸和半胱氨酸的饮食供应。
Int J Biochem Cell Biol. 2004 Oct;36(10):1993-2004. doi: 10.1016/j.biocel.2004.02.019.
10
[The effect of selenium, methionine and vitamin E on methionine metabolism and methionine-adenosyltransferase activity in the rat liver].[硒、蛋氨酸和维生素E对大鼠肝脏蛋氨酸代谢及蛋氨酸-腺苷转移酶活性的影响]
Ukr Biokhim Zh. 1972;44(4):504-8.

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Erasing mA-dependent transcription signature of stress-sensitive genes triggers antidepressant actions.消除应激敏感基因的毫安依赖性转录特征可引发抗抑郁作用。
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Methionine adenosyltransferases in liver cancer.肝癌中的蛋氨酸腺苷转移酶。
World J Gastroenterol. 2019 Aug 21;25(31):4300-4319. doi: 10.3748/wjg.v25.i31.4300.
6
Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A.靶向 Mat2A 的新型别构抑制剂抑制 S-腺苷甲硫氨酸的合成。
Nat Chem Biol. 2017 Jul;13(7):785-792. doi: 10.1038/nchembio.2384. Epub 2017 May 29.
7
S-Adenosyl-L-homocysteine in brain : Regional concentrations, catabolism, and the effects of methionine sulfoximine.脑中 S-腺苷-L-高半胱氨酸：区域浓度、分解代谢以及甲硫氨酸亚砜imine 的影响。
Neurochem Res. 1977 Feb;2(1):27-38. doi: 10.1007/BF00966019.
8
Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression.乙醇抑制甲硫氨酸腺苷转移酶II的活性和S-腺苷甲硫氨酸的生物合成，并增强T淋巴细胞中半胱天冬酶-3依赖性细胞死亡：与酒精诱导的免疫抑制的相关性。
J Nutr Biochem. 2008 Jun;19(6):384-91. doi: 10.1016/j.jnutbio.2007.05.010. Epub 2007 Sep 14.
9
Biosynthesis of ethylene from methionine in aminoethoxyvinylglycine-resistant avocado tissue.在抗氨基乙氧基乙烯基甘氨酸的鳄梨组织中由蛋氨酸合成乙烯
Plant Physiol. 1982 Jan;69(1):93-7. doi: 10.1104/pp.69.1.93.
10
In vivo evidence that S-adenosylmethionine and fatty acid synthesis intermediates are the substrates for the LuxI family of autoinducer synthases.体内证据表明，S-腺苷甲硫氨酸和脂肪酸合成中间体是自诱导物合成酶LuxI家族的底物。
J Bacteriol. 1998 May;180(10):2644-51. doi: 10.1128/JB.180.10.2644-2651.1998.