Patil G S, Sprecher H, Cornwell D G
Lipids. 1979 Sep;14(9):826-8. doi: 10.1007/BF02533524.
Methyl-branched derivatives of methyl 8,11,14-eicosatrienoate form stable liquid-expanded monolayers. Surface areas are expanded by the methyl branch. The expansion effect is a function of surface pressure. At high surface pressure, the greatest expansion occurs with a mid-point methyl branch. At low surface pressure, surface area increases continuously as the methyl group is moved along the carbon chain from carbon 19 to carbon 5. Desaturase activity varies inversely with surface area, and a linear correlation exists between surface area at low surface pressure and the desaturation rate. These data support the concept that lipid structure and its effect on short range forces between molecules is an important factor in desaturase activity.
8,11,14-二十碳三烯酸甲酯的甲基支链衍生物能形成稳定的液体扩张单分子层。甲基支链会使表面积增大。这种扩张效应是表面压力的函数。在高表面压力下，中点甲基支链会产生最大的扩张。在低表面压力下，随着甲基从碳19沿着碳链移动到碳5，表面积会持续增加。去饱和酶活性与表面积成反比，且低表面压力下的表面积与去饱和速率之间存在线性关系。这些数据支持了这样一种观点，即脂质结构及其对分子间短程力的影响是去饱和酶活性的一个重要因素。
