Chowanetz W, Müller K, Gross W
Med Klin. 1979 Sep 7;74(36):1286-90.
In ten healthy volunteers infusion of 7 micrograms/kg orciprenaline produced typical changes in carbohydrate and fat metabolism due to beta-adrenergic stimulation. Pretreatment with intravenously administered propranolol or metoprolol significantly inhibited orciprenaline-induced changes in systolic blood pressure, heart rate and plasma FFA, potassium, glucose and glycerol levels. Propranolol (0.1 mg/kg) seemed to be more effective than metoprolol (0.2 mg/kg) even in inhibiting predominantly beta 1-adrenergic responses.
在10名健康志愿者中，静脉输注7微克/千克的奥西那林，由于β-肾上腺素能刺激，引起了碳水化合物和脂肪代谢的典型变化。静脉注射普萘洛尔或美托洛尔进行预处理，可显著抑制奥西那林引起的收缩压、心率以及血浆游离脂肪酸、钾、葡萄糖和甘油水平的变化。即使在主要抑制β1-肾上腺素能反应方面，普萘洛尔（0.1毫克/千克）似乎也比美托洛尔（0.2毫克/千克）更有效。
