呼吸窘迫综合征中的机械通气：一项对照试验。
Mechanical ventilation in the respiratory distress syndrome: a controlled trial.
作者信息
Murdock A I, Linsao L, Reid M M, Sutton M D, Tilak K S, Ulan O A, Swyer P R
出版信息
Arch Dis Child. 1970 Oct;45(243):624-33. doi: 10.1136/adc.45.243.624.
A controlled study of mechanical ventilation has been performed in infants with respiratory distress syndrome. 168 infants in respiratory failure were ventilated and 53 similar infants were not. Artificial mechanical ventilation improved survival in infants weighing more than 2000 g. from 15% to 43% (4/27 vs. 29/67, p < 0·025). Infants who weighed more than 1500 g. and developed respiratory failure at less than 38 hours of age had an improved survival (16/31) on ventilatory treatment, as compared with infants more than 1500 g. ventilated at more than 38 hours of age (24/78) (p < 0·05). Artificial ventilation improved Po, Pco, and [H] within one hour, but it was only the change in [H] in infants more than 2000 g. which was of prognostic significance. Survival rates were similar for each of the three types of respirator used.
对患有呼吸窘迫综合征的婴儿进行了机械通气对照研究。168例呼吸衰竭婴儿接受了通气治疗，53例类似婴儿未接受通气治疗。人工机械通气使体重超过2000克的婴儿存活率从15%提高到43%（4/27对29/67，p<0.025）。体重超过1500克且在38小时龄前发生呼吸衰竭的婴儿，通气治疗后的存活率（16/31）高于38小时龄后接受通气治疗的体重超过1500克的婴儿（24/78）（p<0.05）。人工通气在1小时内改善了氧分压、二氧化碳分压和[氢离子浓度]，但只有体重超过2000克的婴儿[氢离子浓度]的变化具有预后意义。使用的三种类型的呼吸机的存活率相似。
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