Schöber J G, Kellner M
Monatsschr Kinderheilkd (1902). 1979 Oct;127(10):617-20.
Three infants with preductal coartation, tubular hypoplasia of the aortic arch, and VSD were treated with Prostaglandin E1 (PGE1)-infusion to dilate the ductus arteriosus Botalli. Before PGE1-therapy the infants were treated with Furosemide and Digitalis, but they remained oliguric or anuric. During PGE1-infusion the pressure in the descending aorta rose and urine output increased significantly. Obviously the blood flow into the descending aorta via the ductus arteriosus was improved during PGE1-infusion. In all three cases surgery was successfull after PGE1-therapy. Before PGE1-therapy of preductal coarctation the diagnosis should be clear and also classical therapy with Furosemide and Digitalis should be tried.
三名患有动脉导管前缩窄、主动脉弓管状发育不全和室间隔缺损的婴儿接受了前列腺素E1（PGE1）输注治疗，以扩张动脉导管Botalli。在PGE1治疗前，这些婴儿接受了呋塞米和洋地黄治疗，但他们仍少尿或无尿。在PGE1输注期间，降主动脉压力升高，尿量显著增加。显然，在PGE1输注期间，通过动脉导管进入降主动脉的血流量得到了改善。在所有三例中，PGE1治疗后手术均成功。在对动脉导管前缩窄进行PGE1治疗之前，诊断应明确，还应尝试使用呋塞米和洋地黄进行经典治疗。
