Walli A K, Wieland E, Faulstich H, Wieland T
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;307(3):283-6. doi: 10.1007/BF00505945.
Using [3H]-demethylphalloin as a tracer the uptake of phallotoxins by the liver of young (6, 12, 16 days old) and adult rats was determined in relation to the dose of toxin administered. The maximum amount taken up by the livers of the young rats was only about 50% of that in adults. Nevertheless, with a dose as high as 55 mg/kg body weight the toxin concentration in the young liver reached more than 30 micrograms/g, being markedly higher than the minimum concentration (approximately 20 micrograms/g) required to cause irreversible damage of the liver in adult rats and death of the animals. This suggests that the tolerance of young rats to phallotoxins cannot solely be explained by the reduced uptake of the toxin.
以[³H]-去甲基鬼笔环肽作为示踪剂，测定了幼龄（6日龄、12日龄、16日龄）和成年大鼠肝脏对鬼笔毒素的摄取量与所给予毒素剂量的关系。幼龄大鼠肝脏摄取的最大量仅约为成年大鼠的50%。然而，当给予高达55 mg/kg体重的剂量时，幼龄大鼠肝脏中的毒素浓度达到了30微克/克以上，明显高于成年大鼠肝脏造成不可逆损伤和动物死亡所需的最低浓度（约20微克/克）。这表明幼龄大鼠对鬼笔毒素的耐受性不能仅仅用毒素摄取减少来解释。
