破伤风中毒小鼠存活率的评估。一种筛选抗破伤风药物的模型。
The estimation of the survival rate of tetanus-intoxicated mice. A model for screening anti-tetanus drugs.
作者信息
Huck S
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1979 Jul;308(1):77-9. doi: 10.1007/BF00499723.
PMID:492357
Abstract
The estimation of the survival rate of tetanus-intoxicated mice is suggested to be a useful animal model for assaying the anti-tetanus potency of drugs. This model was tested with the four central depressants phenobarbitone, chlorpromazine, diazepam and halothane. In agreement with their clinical value, diazepam appeared to be the most, phenobarbitone the least effective agent.
摘要
破伤风中毒小鼠存活率的评估被认为是一种用于测定药物抗破伤风效力的有用动物模型。该模型用四种中枢抑制剂苯巴比妥、氯丙嗪、地西泮和氟烷进行了测试。与它们的临床价值一致，地西泮似乎是最有效的药物，苯巴比妥是效果最差的药物。
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