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抗枯草杆菌蛋白酶消化破伤风毒素抗体的毒素中和作用

Toxin-neutralizing effect of antibody against subtilisin-digested tetanus toxin.

作者信息

Sato H, Ito A, Yamakawa Y, Murata R

出版信息

Infect Immun. 1979 Jun;24(3):958-61. doi: 10.1128/iai.24.3.958-961.1979.

DOI:10.1128/iai.24.3.958-961.1979
PMID:468382
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC414401/
Abstract

A form of systemic tetanus with atypical symptoms was observed in mice injected in the left thigh with a mixture of tetanus toxin and antibody produced in guinea pigs against a fragment of toxin obtained from a subtilisin digest of the crystallized toxin. The mice did not show typical symptoms of the local tetanus such as convulsions or spastic paralysis of the injected limb.

摘要

在左大腿注射破伤风毒素与豚鼠产生的针对结晶毒素枯草杆菌蛋白酶消化片段的抗体混合物的小鼠中，观察到一种具有非典型症状的全身性破伤风形式。这些小鼠未表现出局部破伤风的典型症状，如注射肢体的抽搐或痉挛性麻痹。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/efe3f5f26b30/iai00186-0373-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/f0359c6eb401/iai00186-0371-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/c5f55b731d22/iai00186-0372-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/efe3f5f26b30/iai00186-0373-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/f0359c6eb401/iai00186-0371-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/c5f55b731d22/iai00186-0372-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/03ce/414401/efe3f5f26b30/iai00186-0373-a.jpg

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引用本文的文献

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A review of the molecular structure of tetanus toxin.破伤风毒素的分子结构综述。
Mol Cell Biochem. 1982 Oct 1;48(1):33-44. doi: 10.1007/BF00214820.

本文引用的文献

1
Ganglioside as a prophylactic agent in experimental tetanus in mice.神经节苷脂作为小鼠实验性破伤风的预防剂。
J Gen Microbiol. 1968 Dec;54(2):161-8. doi: 10.1099/00221287-54-2-161.
2
Studies on tetanus antitoxins. II. Demonstration of at least four antitoxins of different specificity in antitoxic sera.破伤风抗毒素研究。II. 抗毒素血清中至少四种不同特异性抗毒素的证明。
J Immunol. 1973 May;110(5):1388-95.
3
Isolation and purification of two antigenically active, "complimentary" polypeptide fragments of tetanus neurotoxin.破伤风神经毒素两种具有抗原活性的“互补”多肽片段的分离与纯化。
Infect Immun. 1975 Nov;12(5):1147-53. doi: 10.1128/iai.12.5.1147-1153.1975.
4
Toxicity of papain-digested tetanus toxin. Pathological effect of fragment B in the absence of spastic paralysis.木瓜蛋白酶消化的破伤风毒素的毒性。片段B在无痉挛性麻痹情况下的病理效应。
J Biol Chem. 1978 Jan 10;253(1):125-9.
5
Antigenic substructure of tetanus neurotoxin.破伤风神经毒素的抗原亚结构
Biochem Biophys Res Commun. 1977 Jul 11;77(1):268-74. doi: 10.1016/s0006-291x(77)80192-7.
6
Structure of tetanus toxin. I. Breakdown of the toxin molecule and discrimination between polypeptide fragments.破伤风毒素的结构。I. 毒素分子的分解及多肽片段的鉴别。
J Biol Chem. 1977 Jan 10;252(1):187-93.
7
Structure of tetanus toxin. II. Toxin binding to ganglioside.
J Biol Chem. 1977 Jan 10;252(1):194-8.