Lespier-Dexter L E, Guerra C, Ojeda W, Martinez-Maldonado M
Nephron. 1979;24(2):64-8. doi: 10.1159/000181685.
To evaluate granulocyte function in uremia and hemodialysis we studied granulocyte adherence, an important step in chemotaxis. Our studies demonstrate that patients with severe impairment in renal function had normal granulocyte adherence (72.1 +/- 21 vs. 72.9 +/- 14% controls) while patients with end stage renal disease undergoing hemodialysis (45 +/- 30%) had significant impairment (p less than 0.001). Adherence worsened during dialysis (p less than 0.001) but returned towards the abnormal baseline values at the end of the procedure. There was a significant correlation between adherence and potassium (r=0.77; p less than 0.05) and adherence and sodium-potassium ratio (r=-0.78; p less than 0.05) before and after dialysis. Other factors such as changes in creatinine, urea nitrogen, osmolality, calcium, phosphorus or (H+) did not correlate with adherence. It is concluded that the abnormality in adherence is not the result of the basic disease process but a consequence of dialysis.
为评估尿毒症及血液透析患者的粒细胞功能，我们研究了趋化作用中的一个重要步骤——粒细胞黏附。我们的研究表明，肾功能严重受损的患者粒细胞黏附正常（72.1±21，对照组为72.9±14%），而接受血液透析的终末期肾病患者（45±30%）存在显著受损（p<0.001）。透析过程中黏附情况恶化（p<0.001），但在透析结束时恢复至异常的基线值。透析前后，黏附与钾（r=0.77；p<0.05）以及黏附与钠钾比（r=-0.78；p<0.05）之间存在显著相关性。肌酐、尿素氮、渗透压、钙、磷或(H+)等其他因素与黏附无相关性。得出的结论是，黏附异常并非基础疾病过程的结果，而是透析的后果。
