Wollemann M, Szebeni A, Bajusz S, Gráf L
Neurochem Res. 1979 Oct;4(5):627-31. doi: 10.1007/BF00964439.
Among opiatelike peptides, stimulatory as well as inhibitory effects are encountered on adenylate cyclase activity. These actions are dependent not only on the investigated brain region but also on the applied peptide. Met-enkephalin stimulates adenylate cyclase activity in the rat brain stem (D-Met2, Pro5)-enkephalinamide and beta-endorphin inhibited it, whereas all three peptides inhibited the activity of cortex. Naloxone antagonized the effects of the applied peptides in the presence of sodium chloride.
在类阿片肽中，对腺苷酸环化酶活性既有刺激作用也有抑制作用。这些作用不仅取决于所研究的脑区，还取决于所应用的肽。甲硫氨酸脑啡肽刺激大鼠脑干中的腺苷酸环化酶活性，（D-蛋氨酸2，脯氨酸5）-脑啡肽酰胺和β-内啡肽则抑制该活性，而这三种肽均抑制皮质的活性。在有氯化钠存在的情况下，纳洛酮拮抗所应用肽的作用。
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