铅中毒的新治疗前景：α-巯基丙酰甘氨酸

[New therapeutic prospects in lead poisoning: alpha-mercaptopropionylglycine].

作者信息

Franco G, Malamani T, Scalisi L

出版信息

Minerva Med. 1979 Sep 26;70(41):2811-9.

Abstract

The action of alpha-mercaptopropionylglycine has been studied in 27 subjects occupationally exposed to lead. In addition to improved efficiency of liver function, the results show a tendency to normalization of the various porphyrinic metabolism parameters considered. A significant increase was observed in erythrocyte dehydratase ALA activity together with an equally significant diminution in urinary excretion of delta-aminoleuvlinic acid. Urinary coprorphyrin and erythrocyte protoporphyrin IX values were also down. The tendency of metabolic changes to normalize as a result of the toxic action of lead suggests the use of alpha-mercaptopropionylglycine in the treatment of lead poisoning.

摘要

已对27名职业性接触铅的受试者进行了α-巯基丙酰甘氨酸作用的研究。除肝功能效率提高外，结果显示所考虑的各种卟啉代谢参数有趋于正常化的倾向。观察到红细胞脱水酶ALA活性显著增加，同时δ-氨基乙酰丙酸的尿排泄量同样显著减少。尿粪卟啉和红细胞原卟啉IX值也下降。由于铅的毒性作用，代谢变化趋于正常化的趋势表明α-巯基丙酰甘氨酸可用于治疗铅中毒。

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