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[2-巯基丙酰甘氨酸(硫普罗宁)的抗脂肪变性活性。采用(BSF)动态试验及治疗前后肝活检进行研究]

[The antisteatosic activity of 2-MPG (Thiola). Study with the (BSF) dynamic test and with liver biopsy before and after the treatment].

作者信息

Surrenti C, Arcangeli A, Casini A

出版信息

Minerva Med. 1978 Dec 15;69(61):4251-6.

PMID:733081
Abstract

The short-term therapeutic effect of 2-MPG has been studied in 12 patients suffering from chronic liver disease of prevalent steatosic type. The drug was administered in a dose of 2.5 g. for 20 days. Patients were submitted to hepatic needle biopsy and BSF load test, with compartmental analysis before and after treatment. A marked reduction in steatosis and a statistically significant fall in BSF retention at the 45th minute, with increase in conjugation and excretion of colorant, was observed in 11 patients.

摘要

已对12例患有常见脂肪变性型慢性肝病的患者研究了2-甲氧基戊二酸(2-MPG)的短期治疗效果。药物以2.5克的剂量给药,持续20天。患者接受了肝穿刺活检和溴磺酚酞(BSF)负荷试验,并在治疗前后进行了分区分析。在11例患者中观察到脂肪变性明显减轻,在第45分钟时BSF潴留量有统计学意义的下降,同时染料的结合和排泄增加。

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