Hersh E M
Science. 1971 May 14;172(3984):736-8. doi: 10.1126/science.172.3984.736.
Continuous exposure to 0.1 international unit or more of Escherichia coli L-glutaminase inhibited responses of human lymphocytes to phytohemagglutinin, streptolysin O, and allogeneic leukocytes. Inhibition was completety reversed by removing the enzyme from the culture or adding L-glutamine but not L-asparagine. Cytoxicity did not occur. L-Glutaminase should be immunosuppressive in vivo.
持续暴露于0.1国际单位或更多的大肠杆菌L-谷氨酰胺酶会抑制人类淋巴细胞对植物血凝素、链球菌溶血素O和同种异体白细胞的反应。通过从培养物中去除该酶或添加L-谷氨酰胺而非L-天冬酰胺，抑制完全逆转。未发生细胞毒性。L-谷氨酰胺酶在体内应具有免疫抑制作用。
