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1
Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain.氢溴酸非那佐辛（Narphen）与硫酸吗啡对急性腹痛患者镇痛效果的双盲临床试验。
Gut. 1971 Jan;12(1):51-4. doi: 10.1136/gut.12.1.51.
2
A cross-over comparison of the effect of morphine, pethidine, pentazocine, and phenazocine on biliary pressure.吗啡、哌替啶、喷他佐辛和非那佐辛对胆道压力影响的交叉对照比较。
Gut. 1971 Mar;12(3):218-21. doi: 10.1136/gut.12.3.218.
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Pentazocine and phenazocine. A double-blind comparison of two benzomorphan derivatives in postoperative pain.喷他佐辛和非那佐辛。两种苯并吗啡烷衍生物用于术后疼痛的双盲比较。
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Action of various new analgesic drugs on the human common bile duct.多种新型镇痛药对人体胆总管的作用。
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Narcotic analgesic effects on the sphincter of Oddi: a review of the data and therapeutic implications in treating pancreatitis.麻醉性镇痛药对Oddi括约肌的影响：治疗胰腺炎的数据回顾及治疗意义
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The morphine-prostigmin provocative test--is it useful for making clinical decisions?吗啡-新斯的明激发试验——它对临床决策有帮助吗？
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Opioid analgesics: comparative features and prescribing guidelines.阿片类镇痛药：比较特征与处方指南
Drugs. 1996 May;51(5):713-37. doi: 10.2165/00003495-199651050-00002.
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Clinical pharmacokinetics of drug administered buccally and sublingually.经口腔颊部和舌下给药的药物临床药代动力学。
Clin Pharmacokinet. 1991 Aug;21(2):83-94. doi: 10.2165/00003088-199121020-00001.

本文引用的文献

1
A clinical comparison of two new narcotic analgesics.两种新型麻醉性镇痛药的临床比较
Curr Ther Res Clin Exp. 1959 Dec;1:109-14.
2
The use of phenazocine (prinadol) in surgical patients.非那佐辛（普里纳多）在外科手术患者中的应用。
Surg Gynecol Obstet. 1960 Jun;110:669-72.
3
The clinical measurement of pain.
Ann N Y Acad Sci. 1960 Mar 30;86:28-37. doi: 10.1111/j.1749-6632.1960.tb42788.x.
4
A COMPARISON OF MORPHINE AND PHENAZOCINE IN POSTOPERATIVE PAIN.吗啡与非那佐辛用于术后疼痛的比较
Br J Anaesth. 1964 Dec;36:782-6. doi: 10.1093/bja/36.12.782.
5
Action of various new analgesic drugs on the human common bile duct.多种新型镇痛药对人体胆总管的作用。
Gut. 1967 Jun;8(3):296-300. doi: 10.1136/gut.8.3.296.

氢溴酸非那佐辛（Narphen）与硫酸吗啡对急性腹痛患者镇痛效果的双盲临床试验。

Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain.

作者信息

Hopton D

出版信息

Gut. 1971 Jan;12(1):51-4. doi: 10.1136/gut.12.1.51.

DOI:10.1136/gut.12.1.51
PMID:4929685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1411461/
Abstract

No significant difference could be detected either by clinical impression or statistical analysis in the relief of pain afforded by 2.5 mg phenazocine hydrobromide (Narphen) and 10 mg morphine sulphate when given by intramuscular injection to patients with acute abdominal pain. Phenazocine does not cause spasm of the sphincter of Oddi and so is recommended for treating biliary or pancreatic pain.

摘要

对急性腹痛患者肌内注射2.5毫克氢溴酸非那佐辛（纳芬）和10毫克硫酸吗啡后，无论是临床印象还是统计分析，都未发现二者在缓解疼痛方面有显著差异。非那佐辛不会引起Oddi括约肌痉挛，因此推荐用于治疗胆源性或胰腺性疼痛。