痕量金属对肺泡巨噬细胞吞噬作用的影响。
Effect of trace metals on phagocytosis by alveolar macrophages.
作者信息
Graham J A, Gardner D E, Waters M D, Coffin D L
出版信息
Infect Immun. 1975 Jun;11(6):1278-83. doi: 10.1128/iai.11.6.1278-1283.1975.
Abstract
Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni(2+) selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO(3) (-) that caused extensive lysis and death did not reduce phagocytosis in surviving cells. The effects of Cd(2+), Cr(3+), and Mn(2+) on AMs were also examined.
摘要
进行了实验以测量痕量金属对肺泡巨噬细胞（AM）的一项重要功能——吞噬作用的影响。由于发现某些痕量金属会降低AM的活力，因此开发了一种技术，仅允许对活细胞进行吞噬作用检查。有证据表明，Ni(2+)在低于导致细胞死亡的浓度下选择性地改变了AM的吞噬活性。进一步表明，导致广泛裂解和死亡的VO(3) (-)水平并未降低存活细胞的吞噬作用。还研究了Cd(2+)、Cr(3+)和Mn(2+)对AM的影响。
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