Chittal S M, Oreopoulos D G, DeVeber G A, Thomas P, Rabinovich S, Lloyd G J, Kumar M A, Rapoport A
Can Med Assoc J. 1971 Jun 19;104(12):1098-100.
Whether calcitonin plays a significant role in the pathogenesis of renal osteodystrophy is not known. Plasma calcitonin-like activity (CLA) was measured by means of an extraction procedure and bioassay in 17 patients with chronic renal failure. Recent bone biopsy data were available for 11 patients. Plasma CLA was found to be in the normal range in the patients studied. There was a positive and strong correlation between plasma calcium and plasma CLA. Chronic dialysis and renal transplantation had no significant effect on plasma CLA. The severity and type of bone lesions did not correlate with plasma CLA. Although plasma calcitonin in chronic renal failure does not appear to be directly related to renal osteodystrophy, normal mobilization of calcitonin may protect the skeleton to some degree from the high levels of parathyroid hormone usually present in such patients.
降钙素在肾性骨营养不良的发病机制中是否起重要作用尚不清楚。采用提取法和生物测定法对17例慢性肾衰竭患者的血浆降钙素样活性（CLA）进行了测定。11例患者有近期的骨活检数据。研究发现，所研究患者的血浆CLA在正常范围内。血浆钙与血浆CLA之间存在强正相关。慢性透析和肾移植对血浆CLA无显著影响。骨病变的严重程度和类型与血浆CLA无关。虽然慢性肾衰竭患者的血浆降钙素似乎与肾性骨营养不良无直接关系，但降钙素的正常动员可能在一定程度上保护骨骼免受这类患者通常存在的高水平甲状旁腺激素的影响。
