Delamare J P, Jones G T
Postgrad Med J. 1979 Jul;55(645):487-91. doi: 10.1136/pgmj.55.645.487.
Changes in renal function were observed in 17 subjects during the course of a trek to high altitude. Comparison was made between these changes and the clinical assessment of acute mountain sickness (AMS). Periods of natriuresis occurred during ascent and descent, that during ascent being related to a fall in plasma aldosterone. Alterations in serum and urinary potassium suggested that potassium retention occurred during the ascent to altitude. No significant correlation occurred between changes in renal function and the severity of AMS before the illness being clinically apparent. When this was so, the severity of AMS correlated with a decreasing urine output, increasing positive fluid balance and a decreasing excretion of sodium and potassium; these changes were produced in part by a decrease in glomerular filtration rate.
在17名受试者攀登至高原的过程中观察到了肾功能变化。将这些变化与急性高原病（AMS）的临床评估进行了比较。在上升和下降过程中均出现了利钠期，上升期间的利钠期与血浆醛固酮水平下降有关。血清和尿钾的变化表明在攀登至高原期间发生了钾潴留。在疾病临床症状出现之前，肾功能变化与AMS严重程度之间无显著相关性。当出现这种情况时，AMS的严重程度与尿量减少、液体正平衡增加以及钠和钾排泄减少相关；这些变化部分是由肾小球滤过率降低引起的。
