[糖皮质激素在线粒体DNA复制中的作用]
[Role of glucocorticoids in the mitochondrial DNA replication].
作者信息
Minchenko A G
出版信息
Probl Endokrinol (Mosk). 1979 Sep-Oct;25(5):52-6.
PMID:493255
Abstract
The liver mitochondrial DNA biosynthesis was found to be enhanced in adrenalectomized rats. Cortisol administration to adrenalectomized rats caused a decrease of the liver mitochondrial DNA biosynthesis. Sedimentation analysis of the mitochondrial DNA in CsCl--EtBr gradient has demonstrated that 3H-thymidine incorporation into the mictochondrial DNA increased mainly in the "open circular" molecules fraction.
摘要
研究发现，肾上腺切除大鼠的肝脏线粒体DNA生物合成增强。给肾上腺切除大鼠注射皮质醇会导致肝脏线粒体DNA生物合成减少。在CsCl-EtBr梯度中对线粒体DNA进行沉降分析表明，3H-胸腺嘧啶核苷掺入线粒体DNA主要在“开环”分子部分增加。
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