甲氧苄啶与磺胺甲恶唑治疗慢性支气管炎的双盲交叉试验。
A double-blind cross-over trial of trimethoprim and sulphamethoxazole in chronic bronchitis.
作者信息
Webster I W
出版信息
Thorax. 1971 May;26(3):319-24. doi: 10.1136/thx.26.3.319.
Abstract
A double-blind cross-over trial comparing trimethoprim-sulphamethoxazole with sulphamethoxazole in patients with chronic bronchitis in their usual state of health showed that the combination was more effective in reducing the volume and purulence of the sputum. Although the patients preferred treatment with the combination, there was no objective improvement in respiratory function. There was a significant incidence of side effects.
摘要
一项双盲交叉试验，比较了甲氧苄啶-磺胺甲恶唑与磺胺甲恶唑对处于健康正常状态的慢性支气管炎患者的疗效，结果显示联合用药在减少痰液量和脓性方面更有效。尽管患者更喜欢联合治疗，但呼吸功能并无客观改善。副作用的发生率较高。
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