Kastin A J, Schally A V, Gual C, Midgley A R, Miller M C, Cabez A
J Clin Invest. 1971 Jul;50(7):1551-3. doi: 10.1172/JCI106641.
In previous clinical studies with highly purified porcine luteinizing hormone-releasing hormone (LH-RH), administration of the somewhat arbitrarily chosen doses of 700-1500 mug resulted in increased serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The present study determined the minimum effective dose as well as the relationship of the response of serum LH and FSH to the dose of LH-RH administered. Three normal men received i.v. injections of 1.1-810 mug of LH-RH. A dose of 10 mug of LH-RH caused a statistically significant elevation in serum LH. 30 mug of LH-RH significantly increased serum FSH levels. A highly significant linear trend was observed in the log dose-response curve. The results indicate that both LH and FSH release occurs in man with doses of LH-RH much lower than previously used and that a linear log dose-response relationship can be obtained.
在先前使用高度纯化的猪促黄体生成激素释放激素（LH-RH）的临床研究中，给予700 - 1500微克这种有些随意选定的剂量会导致血清促黄体生成激素（LH）和促卵泡激素（FSH）水平升高。本研究确定了最小有效剂量以及血清LH和FSH的反应与所给予的LH-RH剂量之间的关系。三名正常男性接受了静脉注射1.1 - 810微克的LH-RH。10微克的LH-RH剂量导致血清LH有统计学意义的升高。30微克的LH-RH显著提高了血清FSH水平。在对数剂量反应曲线中观察到高度显著的线性趋势。结果表明，在人体中，LH-RH剂量远低于先前使用的剂量时，LH和FSH的释放就会发生，并且可以获得线性对数剂量反应关系。
