Morrison J D, Loan W B, Dundee J W
Br Med J. 1971 Jul 31;3(5769):287-90. doi: 10.1136/bmj.3.5769.287.
Thirteen analgesic drugs, four of them at two dose levels, four analgesics in combination with antagonist or neuroleptic agents, and saline have been evaluated simultaneously in the relief of postoperative pain. The method of assessment was designed to favour drugs which provided freedom from pain with minimum depression of consciousness. Only levorphanol 2 mg proved significantly superior to pethidine 100 mg, which was used as the standard reference drug. Oxycodone 10 mg, pentazocine 20 mg, and the morphine 10 mg and cyclizine 50 mg combination were the most successful of the remaining drugs. None of the drug combinations was significantly better than the analgesic drug given alone.
同时评估了13种镇痛药，其中4种采用两种剂量水平，4种镇痛药与拮抗剂或抗精神病药物联合使用，以及生理盐水对术后疼痛的缓解作用。评估方法旨在有利于那些在最小程度抑制意识的情况下使患者免于疼痛的药物。仅2毫克左啡诺被证明明显优于用作标准参考药物的100毫克哌替啶。10毫克羟考酮、20毫克喷他佐辛以及10毫克吗啡与50毫克赛克利嗪的组合是其余药物中最有效的。没有一种药物组合比单独使用的镇痛药效果显著更好。
