铅对氨基比林N-脱甲基作用的影响。
The effect of lead on aminopyrine N-demethylation.
作者信息
Moldowan M J, Behr K
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Aug;25(2):343-55.
The effect of various lead salts on "in vitro" aminopyrine N-demethylation was investigated. Lead was administered to male rats as a 1% solution in the drinking water. After seven days of lead treatment it was found that lead chloride and lead acetate had no effect on microsomal aminopyrine N-demethylation while lead nitrate increased aminopyrine metabolism. Intraperitoneal administration of either lead chloride or lead nitrate at a dose of 20 mg./kg. decreased metabolism. Lead chloride by oral administration did not suppress phenobarbital induction of aminopyrine metabolism in rats.
研究了各种铅盐对“体外”氨基比林N-脱甲基作用的影响。以饮用水中1%的溶液形式给雄性大鼠施用铅。铅处理七天后，发现氯化铅和醋酸铅对微粒体氨基比林N-脱甲基作用没有影响，而硝酸铅增加了氨基比林的代谢。以20毫克/千克的剂量腹腔注射氯化铅或硝酸铅会降低代谢。口服氯化铅不会抑制苯巴比妥对大鼠氨基比林代谢的诱导作用。
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