Zimmermann I, Walkenhorst M, Ulmer W T
Respiration. 1979;38(1):1-11. doi: 10.1159/000194052.
The bronchoconstrictoric influence of allergen and acetylcholine aerosol was tested in 16 boxer dogs. The animals were exposed to these substances through a mask. The aerosol was also administered directly to three restricted areas of the trachea. Both substances induced a strong bronchoconstriction when administered through the mouth. Only the allergen showed a similar strong bronchoconstriction when administered to a restricted area in the upper third of the trachea.
在16只拳师犬中测试了变应原和气态乙酰胆碱的支气管收缩作用。通过面罩让这些动物接触这些物质。气态药物也直接施用于气管的三个限定区域。经口给药时,两种物质均引起强烈的支气管收缩。仅变应原在施用于气管上三分之一的限定区域时表现出类似的强烈支气管收缩。