Bartlett D
Respir Physiol. 1979 Aug;37(3):293-302. doi: 10.1016/0034-5687(79)90076-8.
Ventilation, laryngeal resistance and electromyograms of the diaphragm, posterior cricoarytenoid (PCA) and thyroarytenoid (TA) muscles were recorded in anesthetized, spontaneously breathing cats during 100% O2 administration and during steady state inhalation of hypercapnic and hypoxic gas mixtures. As shown previously, hyperoxic hypercapnia lowered expiratory laryngeal resistance (RlarE). Isocapnic hypoxia also lowered RlarE, and hypercapnia superimposed on hypoxia decreased it further. Hypocapnia raised RlarE. Changes in inspiratory laryngeal resistance (RlarI) were similar to those in RlarE, but smaller. When ventilation was stimulated to the same extent by hypoxia and by hypercapnia, RlarE was lower under hypoxic than hypercapnic conditions in most animals. The electromyograms showed that the respiratory oscillations in laryngeal resistance and the laryngeal responses to hypercapnia and hypoxia were determined chiefly by the activity of the PCA muscle, the abductor of the vocal cords. The TA-a representative adductor muscle-was silent under all conditions studied. The results, considered with previous work, indicate that the larynx plays a part in determining the breathing pattern under resting conditions and during respiratory stimulation by hypercapnia and hypoxia.
在麻醉状态下自主呼吸的猫中，记录了在给予100%氧气期间以及在吸入高碳酸血症和低氧气体混合物的稳定状态下，膈肌、后环杓肌（PCA）和甲杓肌（TA）的通气、喉阻力和肌电图。如先前所示，高氧性高碳酸血症降低了呼气期喉阻力（RlarE）。等碳酸血症性低氧也降低了RlarE，而叠加在低氧状态下的高碳酸血症则使其进一步降低。低碳酸血症升高了RlarE。吸气期喉阻力（RlarI）的变化与RlarE相似，但幅度较小。当低氧和高碳酸血症以相同程度刺激通气时，在大多数动物中，低氧条件下的RlarE低于高碳酸血症条件下的RlarE。肌电图显示，喉阻力的呼吸振荡以及喉对高碳酸血症和低氧的反应主要由声带外展肌PCA的活动决定。在所有研究条件下，作为代表性内收肌的TA均无活动。结合先前的研究工作来看，这些结果表明，在静息状态以及高碳酸血症和低氧引起的呼吸刺激过程中，喉部在决定呼吸模式方面发挥了作用。
