颈动脉体与低氧诱导的整合性心肺反应。
Carotid Bodies and the Integrated Cardiorespiratory Response to Hypoxia.
机构信息
Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida , Tampa, Florida.
出版信息
Physiology (Bethesda). 2018 Jul 1;33(4):281-297. doi: 10.1152/physiol.00014.2018.
Abstract
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to "erase" dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research.
摘要
我们对缺氧通气反应的大脑机制、血压的协调变化以及睡眠呼吸暂停中慢性间歇性缺氧等长期后果（如高血压和心力衰竭）的理解的进展，正在推动寻找治疗方法来“消除”分布在颈动脉体和中枢神经系统中的功能失调记忆。我们回顾了当前的网络模型、悬而未决的问题、性别差异以及对转化研究的影响。
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