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一名年轻患者的连续性脑缺血事故:血栓闭塞性脉管炎、血栓闭塞性脉管炎综合征还是青少年动脉粥样硬化?与另外三例也进行了趾髓活检的病例相比,对一例病例的临床、血管造影和解剖学发现的报告(作者译)

[Successive encephalic ischemic accidents in a young patient: Buerger's disease, buergerian syndrome, or juvenile atheroma? A report in clinical, angiographic, and anatomical findings in one case, compared to three other ones, in which a biopsy of the pulp of the toes was also performed (author's transl)].

作者信息

Arnott G, Benoit M, Gosselin B, Merlen J F, Dobbelaere P, Delandsheer E

出版信息

Rev Neurol (Paris). 1979 Mar;135(3):221-36.

PMID:493784
Abstract

A man of 19 years of age was found to have a diffuse livedo, a quadruple asphyxic acrosyndrome, and dementia. Angiography confirmed the presence of distal ischemia with multiple circulatory blocks and a reduced distal network. The patient died at the age of 25 years and histopathological examinations of the vessels demonstrated obstructive atheromatous lesions in the medium sized and small arteries of the brain and viscera. By comparing these findings with those observed in three other cases, in which biopsy of the pulp of the toe was also performed, the hypothesis can be advanced that these juvenile encephalic ischemic accidents are caused by atheroma, which can be detected, at an early stage, by studying the distal arteries in the finger or toe pulp.

摘要

一名19岁男性被发现有弥漫性青斑、四重窒息性肢端综合征和痴呆。血管造影证实存在远端缺血,伴有多处循环障碍和远端血管网减少。该患者于25岁时死亡,血管组织病理学检查显示大脑和内脏的中小动脉有阻塞性动脉粥样硬化病变。通过将这些发现与另外三例也进行了趾髓活检的病例的观察结果进行比较,可以提出这样的假说,即这些青少年脑缺血性意外是由动脉粥样硬化引起的,通过研究手指或趾髓的远端动脉可以在早期检测到这种病变。

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