Svanes K, Leiknes K A, Varhaug J E, Søreide O
Scand J Gastroenterol. 1979;14(5):633-9. doi: 10.3109/00365527909181402.
Cardiac output and blood flow to different regions and layers of the stomach were determined by the microsphere distribution technique. Aspirin tablets were placed in the stomach of anesthetized cats by gastrotomy. In some animals the arterial pressure was reduced to about 60 mmHg for 30 min by bleeding. The gastric mucosal blood flow decreased markedly during the bleeding. Three hours after reinfusion of the blood gastric mucosal erosions were present at the site of contact of the tablet with the mucosa. In most of the non-bled animals no mucosal lesions were found 4 1/2 after aspirin application. No mucosal damage occurred in animals subjected to bleeding without aspirin treatment. It is concluded that the aspirin damage to the gastric mucosa increases under hemorrhagic shock because of mucosal ischemia in the shocked animals.
采用微球分布技术测定心输出量以及胃不同区域和层次的血流量。通过胃切开术将阿司匹林片剂置于麻醉猫的胃内。在一些动物中，通过放血使动脉压降至约60 mmHg并持续30分钟。放血期间胃黏膜血流量显著减少。回输血液3小时后，片剂与黏膜接触部位出现胃黏膜糜烂。在大多数未放血的动物中，应用阿司匹林4个半小时后未发现黏膜损伤。未接受阿司匹林治疗而仅进行放血的动物未出现黏膜损伤。结论是，由于休克动物的黏膜缺血，出血性休克会加重阿司匹林对胃黏膜的损伤。
