Champion M, Richards R L
Scott Med J. 1979 Jan;24(1):9-12. doi: 10.1177/003693307902400103.
Hodgkin's disease is a rare cause of secondary amyloidosis. In Scotland in the period 1961 to 1974 four patients in whom these 2 conditions were associated have been identified. In one of these the presence of amyloidosis was an unexpected finding at a staging laparotomy for Hodgkin's disease. The clinical and pathological features are summarised. The development of amyloid disease is usually suspected by the finding of proteinuria, which is rarely present in uncomplicated Hodgkin's disease. A distinction is made between a nephrotic syndrome due to glomerulopathy, which is an early complication of Hodgkin's disease and improves with treatment of the primary condition, and the nephrotic syndrome due to amyloidosis which occurs late in the course of the illness and is irreversible and rapidly progressive.
霍奇金病是继发性淀粉样变性的罕见病因。在1961年至1974年期间的苏格兰，已确认有4例患者同时患有这两种疾病。其中1例患者在因霍奇金病进行分期剖腹探查时，意外发现存在淀粉样变性。本文总结了其临床和病理特征。淀粉样疾病的发展通常是通过发现蛋白尿而被怀疑，而蛋白尿在单纯性霍奇金病中很少出现。肾小球病变所致的肾病综合征是霍奇金病的早期并发症，随着原发疾病的治疗而改善，应将其与淀粉样变性所致的肾病综合征相区分，后者发生在疾病后期，是不可逆的且进展迅速。
