Martin R R, White A
Appl Microbiol. 1971 Sep;22(3):397-400. doi: 10.1128/am.22.3.397-400.1971.
The use of the quantitative nasal culture was investigated as a means of evaluation of new antimicrobial drugs in man. Cyclacillin was somewhat more active in vitro than penicillin G against penicillin G-resistant organisms. Cyclacillin was highly effective in suppressing staphylococci susceptible to penicillin G in nasal carriers but did not suppress staphylococci resistant to penicillin G. Although in previous studies by others cyclacillin was effective in treating mice infected with penicillin G-resistant staphylococci, in the present studies cyclacillin was not effective in suppressing nasal penicillin G-resistant staphylococci in man at doses which markedly suppressed penicillin G-sensitive organisms.
定量鼻腔培养作为评估新型抗菌药物在人体中应用的一种方法进行了研究。环青霉素在体外对耐青霉素G的菌株比青霉素G略具活性。环青霉素在抑制鼻腔带菌者中对青霉素G敏感的葡萄球菌方面非常有效，但对耐青霉素G的葡萄球菌无效。尽管在其他人先前的研究中环青霉素在治疗感染耐青霉素G葡萄球菌的小鼠方面有效，但在本研究中，环青霉素在显著抑制青霉素G敏感菌的剂量下，对抑制人体鼻腔中耐青霉素G的葡萄球菌无效。
