大肠杆菌同步培养物中的核苷三磷酸库。
Nucleoside triphosphate pools in synchronous cultures of Escherichia coli.
作者信息
Huzyk L, Clark D J
出版信息
J Bacteriol. 1971 Oct;108(1):74-81. doi: 10.1128/jb.108.1.74-81.1971.
Abstract
Endogenous nucleoside triphosphate pools in synchronized cultures of Escherichia coli B/r/1 oscillate as a function of age. Purine nucleoside triphosphates show a gradual 50% increase from zero age to the time of subsequent division, immediately prior to division. In contrast, pyrimidine nucleoside triphosphates undergo a dramatic change of about 50% in the first half of the generation at a time coincident with the termination of a round of deoxyribonucleic acid replication. A 50 to 70% increase starts at the initiation of the next round of deoxyribonucleic acid replication and continues until cell division, in parallel with the purine nucleotides. The fluctuation of pyrimidines between zero age and the middle of the division cycle suggests a functional relationship for pyrimidine metabolism and the regulation of cell division.
摘要
大肠杆菌B/r/1同步培养物中的内源性核苷三磷酸池随菌龄而振荡。嘌呤核苷三磷酸从零菌龄到随后分裂前的分裂时刻逐渐增加50%。相比之下，嘧啶核苷三磷酸在一代的前半段经历约50%的显著变化，这一时期与一轮脱氧核糖核酸复制的终止同时发生。在下一轮脱氧核糖核酸复制开始时开始50%至70%的增加，并一直持续到细胞分裂，与嘌呤核苷酸的情况平行。零菌龄到分裂周期中期之间嘧啶的波动表明嘧啶代谢与细胞分裂调控之间存在功能关系。
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