大肠杆菌中肽转运对质子化氨基的需求。
The requirement for the protonated -amino group for the transport of peptides in Escherichia coli.
作者信息
Payne J W
出版信息
Biochem J. 1971 Jun;123(2):245-53. doi: 10.1042/bj1230245.
Abstract
Many glycine peptides support growth of a glycine auxotroph of Escherichia coli. If the alpha-amino group of these peptides is methylated, the products are still utilized for growth, and also retain comparable ability with the unsubstituted peptides to compete with natural peptides for transport into the cell. In contrast, glycine peptides devoid of an alpha-amino group, or that have the alpha-amino group substituted by one of a number of acyl groups are not utilized, although E. coli possesses intracellular enzymic activity able to release glycine from such compounds; further, these derivatives do not compete with natural peptides for transport into the cell.
摘要
许多甘氨酸肽能支持大肠杆菌甘氨酸营养缺陷型菌株的生长。如果这些肽的α-氨基被甲基化，其产物仍可用于生长，并且与未取代的肽相比，在与天然肽竞争转运进入细胞方面仍保留相当的能力。相比之下，不含α-氨基或α-氨基被多种酰基之一取代的甘氨酸肽不能被利用，尽管大肠杆菌具有能从此类化合物中释放甘氨酸的细胞内酶活性；此外，这些衍生物在与天然肽竞争转运进入细胞方面不起作用。
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