Chiu W H, Wolff M E
Steroids. 1979 Sep;34(3):361-4. doi: 10.1016/0039-128x(79)90086-2.
Using benzyl alcohol as a hydrogen donor in the presence of Pd on charcoal, 7-methyl-6-dehydrotestosterone acetate was selectively reduced to 7 beta-methyltestosterone acetate in 90% yield. The addition of hydrogen atoms to the 6, 7 double bond proceeded from the less hindered alpha-face of the steroid molecule, giving rise to the 7 beta-methyl product. Gas chromatograph analysis indicated small amounts of the 7 alpha-methyl epimer, 7 beta-methyl-5 alpha-dihydrotestosterone acetate and the 5 beta-epimer. The 6,7 double bond was hydrogenated in preference to 4,5 double bond, although both are trisubstituted.
在钯炭存在下，以苯甲醇作为氢供体，7-甲基-6-脱氢睾酮乙酸酯被选择性还原为7β-甲基睾酮乙酸酯，产率为90%。氢原子加成到甾体分子6,7双键的过程是从位阻较小的α面进行的，生成7β-甲基产物。气相色谱分析表明存在少量的7α-甲基差向异构体、7β-甲基-5α-二氢睾酮乙酸酯和5β-差向异构体。尽管6,7双键和4,5双键都是三取代的，但6,7双键优先于4,5双键被氢化。
