腺病毒12 DNA片段转化细胞中的肿瘤特异性移植与表面抗原
Tumor-specific transplantation and surface antigen in cells transformed by the adenovirus 12 DNA fragments.
作者信息
Shiroki K, Shimojo H, Maeta Y, Hamada C
机构信息
Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108, Japan.
出版信息
Virology. 1979 Nov;99(1):188-91. doi: 10.1016/0042-6822(79)90053-9.
Adenovirus type 12 (Ad 12) tumor-specific transplantation antigen (TSTA) and the surface (S) antigen were examined using rat cells transformed with Ad 12 DNA and its fragments. WY3 (3Yl cells transformed with Ad 12 whole DNA), CYl (3Yl cells transformed with the EcoRI-C fragment of Ad 12 DNA), and GY cells (3Yl cells transformed with the HindIII-G fragment of Ad 12 DNA) contained TSTA and S antigen, but HY cells (3Y1 cells transformed with the BpaI-H fragment of Ad12 DNA) did not. These results suggest that TSTA and S antigens contain a protein(s) coded for by a portion of the transforming gene.
利用经腺病毒12型（Ad 12）DNA及其片段转化的大鼠细胞，检测了腺病毒12型肿瘤特异性移植抗原（TSTA）和表面（S）抗原。WY3（用Ad 12全DNA转化的3Y1细胞）、CY1（用Ad 12 DNA的EcoRI-C片段转化的3Y1细胞）和GY细胞（用Ad 12 DNA的HindIII-G片段转化的3Y1细胞）含有TSTA和S抗原，但HY细胞（用Ad12 DNA的BpaI-H片段转化的3Y1细胞）则不含。这些结果表明，TSTA和S抗原包含由部分转化基因编码的一种或多种蛋白质。
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