Urbanitz D, Nolden H P, Fechner I, Urbanitz S, Freiberg J, Sieberth H G
Klin Wochenschr. 1975 Jan 15;53(2):59-65. doi: 10.1007/BF01482710.
Monocyte function studies in vitro have been performed in 21 patients with terminal, dialysis-treated uremia and, in parallel, in 21 healthy normal subjects. In uremia the attachment, spreading activity, and reduction of nitroblue tetrazolium were shown to be significantly enhanced, indicating a metabolic activation of the monocytes. The phagocytosis of IgG-coated red cells, however, was significantly impaired. A modification of the monocyte IgG-receptor in uremic conditions is supposed; its relevance for the immunosuppression in uremic states is discussed.
对21例晚期接受透析治疗的尿毒症患者及21名健康正常受试者同时进行了单核细胞体外功能研究。结果显示，尿毒症患者单核细胞的黏附、铺展活性及硝基蓝四氮唑还原能力显著增强，表明单核细胞代谢活化。然而，其对IgG包被红细胞的吞噬功能却显著受损。推测尿毒症状态下单核细胞IgG受体发生了改变；并讨论了其与尿毒症状态下免疫抑制的相关性。
