亚甲二氧基苯基化合物对虹鳟鱼中邻苯二甲酸酯水解抑制作用的结构要求

Structural requirements for the inhibition of phthalate ester hydrolysis in rainbow trout by methylenedioxyphenyl compounds.

Melancon M J, Lech J J

Xenobiotica. 1979 May;9(5):317-22. doi: 10.3109/00498257909038735.

Abstract

The ability of a number of methylenedioxyphenyl compounds and paraoxon to inhibit the hydrolysis and oxidation of di-2-ethylhexyl phthalate by rainbow trout tissue preparations was examined. 2. In addition to paraoxon, only the methylenedioxyphenyl compounds with long side-chains (piperonyl butoxide and tropital) inhibited the hydrolysis of di-2-ethylhexyl phthalate by trout liver subcellular fractions and trout serum. 3. Paraoxon decreased the production of the major metabolite of di-2-ethylhexyl phthalate by trout liver microsomes (+ NADPH) suggesting that this metabolite arises via further metabolism of mono-2-ethylhexyl phthalate.

摘要

研究了多种亚甲二氧基苯基化合物和对氧磷抑制虹鳟鱼组织制剂对邻苯二甲酸二（2-乙基己基）酯的水解和氧化的能力。2. 除对氧磷外，只有具有长侧链的亚甲二氧基苯基化合物（胡椒基丁醚和托吡酯）抑制虹鳟鱼肝亚细胞组分和虹鳟鱼血清对邻苯二甲酸二（2-乙基己基）酯的水解。3. 对氧磷降低了虹鳟鱼肝微粒体（+NADPH）对邻苯二甲酸二（2-乙基己基）酯主要代谢产物的生成，表明该代谢产物是通过邻苯二甲酸单（2-乙基己基）酯的进一步代谢产生的。