Eckert H, Lux M, Käppler W, Reutgen H, Noack H
Z Erkr Atmungsorgane. 1979 Mar;152(3):257-62.
Mice and guinea pigs were sensibilisized by intraperitoneal injection of Mycobacterium avium (serotype I). Three and five weeks later (guinea pigs) and four weeks later (mice) the animals received kveim antigen into the footpads (guinea pigs) and into the perianal fat tissue (mice). Three and five weeks later (guinea pigs) and four weeks later (mice) the exstirpated material was investigated by light microscopy and enzyme histochemistry. Guinea pigs showed three and five weeks after injection of kveim antigen a lot of questionable positive and positive kveim tests and mice a high percentage of granulomatous changes, resembling a positive kveim reaction. With histochemical methods leucinaminopeptidase is a valuable diagnostic aid for detection of granulomatous changes in mice but not so good in guinea pigs.
通过腹腔注射鸟分枝杆菌（血清型I）使小鼠和豚鼠致敏。3周和5周后（豚鼠）以及4周后（小鼠），将克维姆抗原注射到脚垫（豚鼠）和肛周脂肪组织（小鼠）中。3周和5周后（豚鼠）以及4周后（小鼠），对切除的组织进行光学显微镜检查和酶组织化学分析。注射克维姆抗原3周和5周后，豚鼠出现许多可疑阳性和阳性的克维姆试验结果，而小鼠则出现高比例的肉芽肿性变化，类似于阳性克维姆反应。组织化学方法显示，亮氨氨肽酶对检测小鼠的肉芽肿性变化是一种有价值的诊断辅助手段，但对豚鼠效果不佳。
