McQuistion T E, McDougald L R
Z Parasitenkd. 1979 Aug;59(2):107-13. doi: 10.1007/BF00927392.
Surgical ligation of chick ceca was used to study the role of absorption and extraintestinal transport in the action of anticoccidial drugs. The administration of drugs in the feed was started after ligation of one of the paried ceca. Birds were inoculated orally with oocysts of Eimeria tenella before cecal ligation or were given bilateral cecal injections of sporozoites after ligation. Cecal lesions caused by the coccidia were evaluated and compared on day 6 postinoculation. Lesions in ligated and unligated ceca were reduced by feeding robenidine (33 ppm), arprinocid (70 ppm), zoalene (125 ppm), aklomide (250 ppm), clopidol (125 ppm), nicarbazin (125 ppm), monensin (120 ppm), salinomycin (60 ppm), and lasalocid (75 ppm). The lesions were more severe in the ligated cecum than in the intact cecum, whether in nonmedicated or medicated birds, but the differences were statistically significant only upon treatment with amprolium, aklomide, robenidine, and clopidol. Generally, however, all drugs except amprolium, significantly reduced the lesions in the ligated cecum in comparison with the control, nonmedicated ligated cecum. Therefore, we concluded that the systemic absorption of most anticoccidial drugs contributes significantly to their efficacy against coccidia in the intestinal mucosa.
采用手术结扎雏鸡盲肠的方法，研究吸收和肠外转运在抗球虫药作用中的作用。在结扎一对盲肠中的一个之后，开始在饲料中添加药物。在盲肠结扎前，给鸡口服柔嫩艾美耳球虫的卵囊，或者在结扎后给鸡双侧盲肠注射子孢子。在接种后第6天，评估并比较由球虫引起的盲肠病变。通过饲喂罗苯尼丁（33 ppm）、阿普林诺（70 ppm）、佐阿勒烯（125 ppm）、阿克洛胺（250 ppm）、氯羟吡啶（125 ppm）、尼卡巴嗪（125 ppm）、莫能菌素（120 ppm）、盐霉素（60 ppm）和拉沙洛西（75 ppm），可减轻结扎和未结扎盲肠的病变。无论是否用药，结扎盲肠中的病变都比完整盲肠中的病变更严重，但仅在用氨丙啉、阿克洛胺、罗苯尼丁和氯羟吡啶治疗时，差异具有统计学意义。然而，一般来说，除氨丙啉外，所有药物与未用药的结扎盲肠对照组相比，都显著减轻了结扎盲肠中的病变。因此，我们得出结论，大多数抗球虫药的全身吸收对其在肠黏膜中抗球虫的疗效有显著贡献。
