Wright I G, Goodger B V
Z Parasitenkd. 1979 Aug;59(2):115-9. doi: 10.1007/BF00927393.
Splenectomised calves in metabolism cages were infected with Babesia bovis. During the infection, urine samples were collected and analysed for electrolytes, proteins, kinin, and urinary kallikrein. During the later stages of the infection there were significant reductions in urinary volume, water intake, urinary kinin, kallikrein, and electrolytes. Proteinuria was detected from 3--8 days postinfection of which 15--20% was haemoglobin and most of the remainder was albumin (70--75%). Fibrin degradation products, fibrinogen-like products, and haptoglobin were not detected. Degeneration of cortical tubules was detected by histological studies. As these tubules produce urinary kallikrein it seems probable that diminished glomerular blood flow and hence glomerular filtration rate are due to decreased production of this enzyme.
将处于代谢笼中的脾切除小牛感染牛巴贝斯虫。在感染期间，收集尿液样本并分析其中的电解质、蛋白质、激肽和尿激肽释放酶。在感染后期，尿量、饮水量、尿激肽、激肽释放酶和电解质均显著减少。感染后3 - 8天检测到蛋白尿，其中15 - 20%为血红蛋白，其余大部分为白蛋白(70 - 75%)。未检测到纤维蛋白降解产物、纤维蛋白原样产物和触珠蛋白。组织学研究检测到皮质肾小管变性。由于这些肾小管产生尿激肽释放酶，肾小球血流量减少进而肾小球滤过率降低似乎很可能是由于这种酶的产生减少所致。
