肿瘤生长和同种异体移植排斥反应期间大鼠的脾脏重量。
Spleen weight in rats during tumour growth and in homograft rejection.
作者信息
Blamey R W, Evans D M
出版信息
Br J Cancer. 1971 Sep;25(3):527-32. doi: 10.1038/bjc.1971.67.
The spleens of rats bearing methylcholanthrene induced sarcomas are enlarged. This applies both to primary and to isotransplanted tumours. The spleen enlarges with increasing tumour size.Splenomegaly is induced by skin homograft rejection, but spleen sizes do not reach those seen during tumour growth, even when the animals are chronically exposed to homologous skin. Sensitization of animals with small tumour homografts gives spleen sizes even greater than those of primary tumour growth.Spleen histology in tumour bearing animals is comparable with that of homograft rejection.The relation of splenomegaly to the presence of tumour specific antigen is discussed. The suggestion is advanced that the spleen size during tumour growth is determined by the product of reaction to foreign antigen, and of reticuloendothelial (phagocytic) activity.
携带甲基胆蒽诱导肉瘤的大鼠脾脏会肿大。这适用于原发性肿瘤和同基因移植肿瘤。脾脏会随着肿瘤大小的增加而肿大。皮肤同种异体移植排斥反应会导致脾肿大，但即使动物长期接触同种皮肤，脾脏大小也不会达到肿瘤生长期间所见的大小。用小的肿瘤同种异体移植对动物进行致敏，会使脾脏大小甚至比原发性肿瘤生长时更大。荷瘤动物的脾脏组织学与同种异体移植排斥反应的组织学相似。文中讨论了脾肿大与肿瘤特异性抗原存在之间的关系。有人提出，肿瘤生长期间的脾脏大小由对外源抗原的反应产物和网状内皮（吞噬）活性决定。
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