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[患有“结合性”黄疸的早产儿的神经系统病变]

[Lesions of the nervous system in premature children with "conjugated" jaundices].

作者信息

Edel'shteĭn E A, Bondarenko E S, Mumladze T A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(10):1368-70.

PMID:494912
Abstract

Results of many-year observation of 110 prematurely born children who had had nuclear jaundice in the precence of hyperbilirubinemia showed that this pathology not only had distinct temporal parameters, but in most cases also a characteristic clinical picture. The principal symptoms are: an abrupt tossing of the head back, general tonic convulsions, tonic stretching of the arms with pronation of the hands, monotonous constrained cry, amimic face, paroxysms of apnoe, and gross impairments on the part of the brain stem. The most important for the diagnosis and prognosis was the "setting sun" symptom. The diagnosing is difficult when the nuclear jaundice joins pre- or intranatal damage to the nervous system or is combined with an infectious toxicosis. Observation of infants during the first six months makes it possible to confirm the diagnosis. The gravity of the sequelae makes it necessary to transfer infants from the maternity home to pediatric hospitals even if the jaundice is only suspected.

摘要

对110名曾患核黄疸且伴有高胆红素血症的早产儿进行多年观察的结果表明,这种病症不仅有明显的时间参数,而且在大多数情况下还有典型的临床表现。主要症状有:头部突然向后甩、全身性强直性惊厥、手臂强直性伸展且手掌内旋、单调受限的哭声、表情呆板的面容、呼吸暂停发作以及脑干严重受损。对诊断和预后最重要的是“落日”症状。当核黄疸合并产前或产时神经系统损伤或与感染性中毒合并时,诊断困难。在头六个月对婴儿进行观察有助于确诊。后遗症的严重性使得即使仅怀疑有黄疸,也有必要将婴儿从产院转至儿科医院。

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