Burtsev E M, Shprakh V V
Zh Nevropatol Psikhiatr Im S S Korsakova. 1979;79(9):1311-5.
Extensive coagulogramms and thromboelastogramms were analysed in 775 patients who had ischemic brain strokes in the age up to 45 years (I group), 46-60 (II group) and over 60 (III group). In patients of the II and III group thrombogenic hypercoagulant tendencies compared to that of the young age were more distinct and were mainly conditioned by depressions of the anticoagulative link in the anticoagulant blood system. In patients younger than 45, despite more rapid formation of procoagulants, there was an earlier and more expressed activation of fibrinolysis and an increase of the concentration of free heparin in the blood. These changes of coagulation in an ischemic stroke have a compensatory significance and can be explained by a prevalent adaptive tendency of changes in metabolism in young age, providing an adaptation of the organism in the period of stress.
对775例年龄在45岁及以下（I组）、46 - 60岁（II组）和60岁以上（III组）的缺血性脑卒中患者进行了广泛的凝血图和血栓弹力图分析。与年轻患者相比，II组和III组患者的血栓形成性高凝倾向更为明显，主要是由抗凝血血液系统中抗凝环节的抑制所导致。在45岁以下的患者中，尽管促凝剂形成更快，但纤溶激活更早且更明显，血液中游离肝素浓度增加。缺血性脑卒中时凝血的这些变化具有代偿意义，这可以通过年轻时代谢变化普遍的适应性倾向来解释，即机体在应激期的一种适应。
