Griepp R B, Stinson E B, Clark D A, Shumway N E
Calif Med. 1970 Aug;113(2):17-26.
During the first two years of clinical cardiac transplantation 20 patients had the operation at Stanford. Operative techniques were successfully translated from extensive laboratory experience to clinical application. Operative indications and contraindications were defined. The diagnosis and treatment of acute cardiac rejection were successful in most cases. Infection, unremitting acute rejection, and chronic rejection remain the major problems in clinical cardiac transplantation. In 20 patients operated upon, survival at six months was 42 percent. At one year it was 35 percent and at 18 months still 35 percent. These figures contrast with those for patients who were accepted as transplantation recipients but died before a suitable donor became available. In this group the 30-day survival was 50 percent, and the 90-day survival was zero. For patients with severe myocardial insufficiency for which alternative methods of therapy are not available, cardiac transplantation results in significantly increased survival and offers an opportunity for return to productive activity.
在临床心脏移植的头两年里，有20名患者在斯坦福大学接受了手术。手术技术成功地从丰富的实验室经验转化为临床应用。明确了手术适应症和禁忌症。大多数情况下，急性心脏排斥反应的诊断和治疗都很成功。感染、持续的急性排斥反应和慢性排斥反应仍然是临床心脏移植的主要问题。在接受手术的20名患者中，六个月时的生存率为42%。一年时为35%，18个月时仍为35%。这些数字与那些被接受为移植受者但在找到合适供体之前死亡的患者形成了对比。在这组患者中，30天生存率为50%，90天生存率为零。对于那些没有其他替代治疗方法的严重心肌功能不全患者，心脏移植可显著提高生存率，并为恢复有生产价值的活动提供机会。
